1. NAME AND TITLE

 MIRDOSE 3.1: Code System to Calculates Internal Dose Estimates by the MIRD Technique.

2. CONTRIBUTOR

 Oak Ridge Institute of Science and Education, Oak Ridge, Tennessee.

3. CODING LANGUAGE AND COMPUTER

 BASIC; PC 386 (C00528/PC386/02).

4. NATURE OF PROBLEM SOLVED

 MIRDOSE 3.1 allows the user to choose from 28 source organs and calculates the radiation absorbed dose to 28 target organs, plus the effective dose and effective dose equivalent for ten phantoms representing adults, children, and pregnant women. If dose estimates are to be generated, the user enters values of residence times in all of the source organs. Dose estimates are displayed on screen for all of the target organs available, with the source organs responsible for the first and second highest contributions listed automatically for each target organ. This information may be sent to a printer or a text file, at the user's choice. Also listed automatically are all of the residence times used by the program in the dose calculations and all other pertinent assumptions. The user may also view contributions of all source organs to any target organs's total dose through a second output screen. The user may also view a listing and a plot of the marrow dose distribution throughout the skeleton, if bone or marrow sources were involved. As an alternative to calculating dose estimates, the user may display (and print or send to a file) tables of S-values (dose conversion factors) for any given phantom and radionuclide. MIRDOSE 3 is a significant update from MIRDOSE 2 in four aspects: (1) the three models for the pregnant female have become available, (2) a new bone and marrow model, developed by Keith Eckerman and others at Oak Ridge National Laboratory, is included, (3) the ability to calculate dose estimates for small, unit density spheres (e.g. tumors) is provided and (4) the user interface in Windows is a significant improvement.  Several corrections and enhancements were made to create the 3.1 version.  Details are included in the README.UPD file.

5. METHOD OF SOLUTION

 MIRDOSE 3.1 calculates internal dose estimates by the Medical Internal Radiation Dose (MIRD) scheme. Data files for skeletal dose conversion factors, specific absorbed fractions, decay data, and a library for organ masses, G1 transit times and various other parameters are included in the package.

6. RESTRICTIONS OR LIMITATIONS

 The program contains decay data for 224 radionuclides, has specific absorbed fractions for 10 phantoms, for 28 source and 28 target organs.

7. TYPICAL RUNNING TIME

 The program is interactive, and produces results for most problems on modern PC's in a matter of seconds.

8. COMPUTER HARDWARE REQUIREMENTS

 The code runs on an IBM PC or compatible under the Windows operating system. Therefore, a 386 or higher processor is required.

 9. COMPUTER SOFTWARE REQUIREMENTS

 The code is compiled in Visual Basic, which was used to create the executable included in this package. The source code is not included. The program must be run under the Windows operating system, version 3.0 or higher.

10. REFERENCES

 a. Included in documentation:

 J. B. Stubbs, "Services and Information Available on DOS-NET."

M. G. Stabin, "README31.UPD" (April 21, 1998).

 M. G. Stabin, "MIRDOSE 3 Documentation Package," ORISE Unpublished Report (December 21, 1994).

b. Background information:

 R. Loevinger, T. Budinger, E. Watson, "MIRD Primer for Absorbed Dose Calculations," Society of Nuclear Medicine, (1988).

 D. Weber, K. Eckerman, L.T. Dillman, J. Ryman, "MIRD: Radionuclide Data and Decay Schemes." Society of Nuclear Medicine (1989).

 M. Cristy, K. Eckerman, "Specific Absorbed Fractions of Energy at Various Ages form Internal Photons Sources," ORNL/TM-8381 V1-V7 (1987).

 M. Stabin, E. Watson, M. Cristy, J. Ryman, K. Eckerman, J. Davis, D. Marshall, K. Gehlen, "Mathematical Models of the Adult Female at Various Stages of Pregnancy," ORNL/TM-12907 (1995)(in press).

 K. F. Eckerman, "Aspects of Dosimetry of Radionuclides Within the Skeleton with Particular Emphasis on the Active Marrow," In Fourth International Radiopharmaceutical Dosimetry Symposium; A. T. Schlafke-Stelson and E. E. Watson eds., CONF-851113, Oak Ridge Associated Universities, Oak Ridge, TN, (1986) pp 514-534.

 J. A. Siegel and M. G. Stabin, "Absorbed Fractions for Electrons and Beta Particles in Small Spheres," J. Nucl. Med. 29, 803 (1988). (abstract)

11. CONTENTS OF CODE PACKAGE

 Included are the referenced documents (a) and two DS/HD 3.5-in. (1.44 MB) diskettes written in DOS format which contain the executable, data files, and documentation.

12. DATE OF ABSTRACT

 March 1988, May 1995, April 1998.

KEYWORDS: INTERNAL DOSE; PHANTOM; RADIONUCLIDES; INTERACTIVE; MICROCOMPUTER